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If you are truly hypothyroid, discontinuing your thyroid medication for a longer period of time can have serious consequences. Anyways to make a long story short, I had a total thyroidectomy and have been taking synthroid 100mcg (was just dropped down from 112mcg). In the study, 291 patients were asked to stop their levothyroxine/synthroid medication for 6-8 weeks. You will have to make arrangements to take some time off from work, to see your doctor. Now my primary care physician has moved and I can’t get my prescription renewed you can't go very long without your thyroid medication. Avoid administration of Synthroid within 4 hours of taking iron or calcium supplements or antacids. Within a few days to weeks, you can expect symptoms of hypothyroidism, including: Fatigue Brain fog Depression and/or anxiety Constipation Dry skin and hair Hair loss Weight gain. My thyroid was removed in 1994 because I had thyroid cancer and I was put on synthroid after that. 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Userdeletedalias63786577 However, without thyroid replacement medication, a person with overt hypothyroidism cannot function optimally and will suffer from the physical and mental symptomsof hypothyroidism. I don’t know how long someone can survive without a thyroid but I think I am going to find out. It can take several weeks to determine if the amount is therapeutic or not. When you fail to sleep for 11 days which is highly unlikely, you should expect the following conditions: Memory loss problems. This is because everyone is different; people have different diets,. You should also make sure you have the medication level checked every 3 months, or whenever your doctor tells you to come back because you will likely have symptoms if the level is off either way. A few days you should be good but I wouldn’t wait too long. 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